PF 03716556
Product Specifications
UNSPSC Description
PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research[1].
Target Antigen
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-03716556.html
Purity
99.10
Solubility
DMSO : 23 mg/mL (ultrasonic;warming)
Smiles
CC1=CN2C=C(C=C(C2=N1)N[C@H]3C4=C(C=CC=C4OCC3)C)C(N(CCO)C)=O
Molecular Weight
394.47
References & Citations
[1]Hiroki Mori, et al. N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13100/PF-03716556-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13100/PF-03716556-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
928774-43-0
Available Sizes
Curated Selection
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