Thalidomide-O-amido-PEG4-C2-NH2 (hydrochloride)
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2245697-85-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-amido-peg4-c2-nh2-hydrochloride.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
Molecular Formula
C25H35ClN4O10
Molecular Weight
587.02
Precautions
H302, H315, H319, H335
References & Citations
[1]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO2016105518A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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