BRD 4354
BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
Product Specifications
CAS Number
315698-07-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRD_4354.html
Purity
98.10
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Molecular Formula
C21H23ClN4O
Molecular Weight
382.89
Precautions
H315, H319, H335
References & Citations
[1]Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11 (7) :1844-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC5; HDAC9
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
abx195579-01 96 Tests
Rat Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
Sign In for Pricing
View Details abx195579-02 5x 96 Tests
Rat Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
Sign In for Pricing
View Details abx195579-03 10x 96 Tests
Rat Tissue Factor Pathway Inhibitor (TFPI) CLIA Kit
Sign In for Pricing
View Details 
MBS7101806 Inquire
Recombinant Schizosaccharomyces pombe Mitochondrial respiratory chain complexes assembly protein rca1 (SPBC543.09), partial
Sign In for Pricing
View Details