BRD 4354
BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
Product Specifications
CAS Number
315698-07-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRD_4354.html
Purity
98.10
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Molecular Formula
C21H23ClN4O
Molecular Weight
382.89
Precautions
H315, H319, H335
References & Citations
[1]Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11 (7) :1844-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC5; HDAC9
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2811536-01 48 Tests
Human Tumor Susceptibility Gene 101 (TSG101) ELISA Kit
Sign In for Pricing
View Details 
orb2811536-02 96 Tests
Human Tumor Susceptibility Gene 101 (TSG101) ELISA Kit
Sign In for Pricing
View Details orb2811536-03 5 x 96 T
Human Tumor Susceptibility Gene 101 (TSG101) ELISA Kit
Sign In for Pricing
View Details NBP3-12057FR 0.1 mL
Rabbit Monoclonal L1CAM Antibody (L1-14.10) [DyLight 680]
Sign In for Pricing
View Details