CP-547632 (TFA)
CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs) . CP-547632 TFA has antitumor efficacy[1].
Product Specifications
CAS Number
[2805804-54-8]
UNSPSC
12352005
Target
FGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-547632-tfa.html
Concentration
10mM
Purity
99.42
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
FC(F)(C(O)=O)F.O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3
Molecular Formula
C22H25BrF5N5O5S
Molecular Weight
646.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
FGFR; VEGFR2/KDR/Flk-1
Available Sizes
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Multi Cation IC Standard Solution 6 components (Lithium (Li+) 10 mg/l; Sodium (Na+) 20 mg/l; Ammonium (Nh4 +) 40 mg/l; Calcium (Ca2+) 40 mg/l; Magnesium (Mg2+) 20 mg/l; Potassium (K+) 20 mg/lin Nitric acid 0.1%) Traceable to NIST