Sisomicin

Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria[1][2].

Product Specifications

CAS Number

[32385-11-8]

Product Name Alternative

Antibiotic 6640; Rickamicin

UNSPSC

12352005

Hazard Statement

H312, H332, H360

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sisomicin.html

Purity

98.45

Solubility

10 mM in DMSO

Smiles

O[C@@H]([C@@H]1O[C@@]2([H])OC(CN)=CC[C@H]2N)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O

Molecular Formula

C19H37N5O7

Molecular Weight

447.53

Precautions

H312, H332, H360

References & Citations

[1]Crowe CC, et al. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3 (1) :24-8.|[2]P Noone, et al. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun;27 (6) :548-78.|[3]Le Moli S, et al. In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis. Int J Immunopharmacol. 1983;5 (1) :49-54.|[4]Fabre J, et al. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 1976 Dec;10 (6) :444-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Aminoglycoside

Citation 01

ACS Infect Dis. 2024 Apr 12;10 (4) :1327-1338.|ACS Biomater Sci Eng. 2024 Apr 24.|Curr Microbiol. 2021 Dec 14;79 (1) :12.|Research Square Preprint. 2024 Apr 1.|STAR Protoc. 2024 Jun 7;5 (2) :103118.