N-Formyl-Met-Leu-Phe

N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR) . N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

Product Specifications

CAS Number

[59880-97-6]

Product Name Alternative

FMLP; N-Formyl-MLF

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

TNF Receptor

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/N-Formyl-Met-Leu-Phe.html

Purity

99.90

Solubility

DMSO : 133.33 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCSC)NC=O)=O)=O

Molecular Formula

C21H31N3O5S

Molecular Weight

437.55

Precautions

H302, H315, H319

References & Citations

[1]Shin MK, et al. N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow. J Biol Chem. 2011 May 13;286 (19) :17133-43.|[2]Chen LY, et al. Synergistic induction of inflammation by bacterial products lipopolysaccharide and fMLP: an important microbial pathogenic mechanism. J Immunol. 2009 Feb 15;182 (4) :2518-24.|[3]Hetland G, et al. Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro. Mol Pathol. 1998 Jun;51 (3) :143-8.