Nyasol

Nyasol ((-) -Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056) -stimulated BV-2 microglial cells[1][2].

Product Specifications

CAS Number

[96895-25-9]

Product Name Alternative

(-) -Nyasol; (Z) -Hinokiresinol; cis-Hinokiresinol

UNSPSC

12352005

Target

Bacterial; Fungal; Leukotriene Receptor; NO Synthase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nyasol.html

Solubility

10 mM in DMSO

Smiles

C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2

Molecular Formula

C17H16O2

Molecular Weight

252.31

References & Citations

[1]Lim H, et al. (-) -Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32 (11) :1509-14.|[2]Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66 (5) :435-8.|[3]Lee HJ, et al. (-) -Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28 (5) :954-9.