Taprenepag
Taprenepag (CP-544326) is a potent and selective prostaglandin EP (2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors[1].
Product Specifications
CAS Number
752187-80-7
Product Name Alternative
CP-544326
UNSPSC
12352005
Hazard Statement
H303, H320
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Taprenepag.html
Concentration
10mM
Purity
98.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CN=CC=C1)(N(CC2=CC(OCC(O)=O)=CC=C2)CC3=CC=C(N4C=CC=N4)C=C3)=O
Molecular Formula
C24H22N4O5S
Molecular Weight
478.52
Precautions
H303, H320
References & Citations
[1]Prasanna G, et al. Effect of PF-04217329 a prodrug of a selective prostaglandin EP (2) agonist on intraocular pressure inpreclinical models of glaucoma. Exp Eye Res. 2011 Sep;93 (3) :256-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
EP
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