Taprenepag

Taprenepag (CP-544326) is a potent and selective prostaglandin EP (2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors[1].

Product Specifications

CAS Number

[752187-80-7]

Product Name Alternative

CP-544326

UNSPSC

12352005

Hazard Statement

H303, H320

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Taprenepag.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CN=CC=C1)(N(CC2=CC(OCC(O)=O)=CC=C2)CC3=CC=C(N4C=CC=N4)C=C3)=O

Molecular Formula

C24H22N4O5S

Molecular Weight

478.52

Precautions

H303, H320

References & Citations

[1]Prasanna G, et al. Effect of PF-04217329 a prodrug of a selective prostaglandin EP (2) agonist on intraocular pressure inpreclinical models of glaucoma. Exp Eye Res. 2011 Sep;93 (3) :256-64.