TRPM4-IN-2

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

Product Specifications

CAS Number

[667411-04-3]

Product Name Alternative

NBA

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trpm4-in-2.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O

Molecular Formula

C19H14ClNO4

Molecular Weight

355.77

References & Citations

[1]Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433 (17) :166665.|[2]Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel) . 2021 Oct 28;13 (21) :5400.