ViFSP1

ViFSP1 is a species-independent FSP1 inhibitor. viFSP1 directly inhibits FSP1 by targeting the highly conserved NAD (P) H binding pocket of FSP1. viFSP1 can induce Ferroptosis in FSP1-dependent cells. viFSP1 can be used in renal and breast cancer research[1][2].

Product Specifications

CAS Number

[951945-67-8]

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vifsp1.html

Purity

99.45

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C2=NC(C)=CS2)=C(N(C1)C3=CC=C(C=C3OC)OC)N

Molecular Formula

C16H17N3O3S

Molecular Weight

331.39

References & Citations

[1]Nakamura T et al. Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nat Struct Mol Biol. 2023 Nov;30 (11) :1806-1815.|[2]Chen X, et al. SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1. Redox Biol. 2024 Sep;75:103267.