BP Fluor 488 TCO

BP Fluor 488 TCO reacts with tetrazine to form a stable covalent bond through what is known as an inverse electron-demand Diels-Alder cycloaddition. This reaction is exceptionally rapid (k > 800 M-1 s-1), highly selective, and biocompatible, requiring neither Cu catalysts nor elevated temperatures. No other bioorthogonal reaction pair described to date matches this outstanding rate constant.