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Anti-inflammatory agent 70

Anti-inflammatory agent 70 (N-Me-SP23) is a STING protein PROTAC degrader and inhibits the STING signaling pathway. Anti-inflammatory agent 70 has anti-inflammatory activity. (Pink: STING inhibitor (HY-47709) ; Black: linker (HY-W008296) ; Blue: CRBN Ligand (HY-W460193) ) [1].

Product Specifications

CAS Number

[2767427-87-0]

UNSPSC

12352005

Target

PROTACs; STING

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-70.html

Purity

97.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[O-][N+](C1=CC=C(C(NC2=CC=C(NC(/C=C/C(NCCCCCCNC3=C4C(C(N(C4=O)C5CCC(N(C5=O)C)=O)=O)=CC=C3)=O)=O)C=C2)=O)O1)=O

Molecular Formula

C35H35N7O10

Molecular Weight

713.69

References & Citations

[1]Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65 (9) :6593-6611.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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