Didox
Didox (NSC-324360) is a synthetic ribonucleotide reductase (RR) inhibitor.
Product Specifications
CAS Number
[69839-83-4]
Product Name Alternative
NSC-324360
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Didox.html
Concentration
10mM
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NO)C1=CC=C(O)C(O)=C1
Molecular Formula
C7H7NO4
Molecular Weight
169.13
Precautions
H302, H312, H332
References & Citations
[1]Matsebatlela TM, et al. 3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. Chem Biol Interact. 2015 May 25;233:95-105.|[2]Cook GJ, et al. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PLoS One. 2014 Nov 17;9 (11) :e112619.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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