Neuroprotective agent 5
Product Specifications
UNSPSC Description
Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease[1].
Target Antigen
Amyloid-β; Cholinesterase (ChE); COX; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation;Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/neuroprotective-agent-5.html
Smiles
FCCO/N=C(CN1C=CN=C1)/C2=CC(OCO3)=C3C=C2
Molecular Weight
291.28
References & Citations
[1]Bian Z Y, et al. Design, Synthesis, and Biological Evaluation of Imidazolylacetophenone Oxime Derivatives as Novel Brain-Penetrant Agents for Alzheimer’s Disease Treatment[J]. European Journal of Medicinal Chemistry, 2024: 116794.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169103/Neuroprotective-agent-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169103/
Clinical Information
No Development Reported
Curated Selection
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