Neuroprotective agent 5

Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; COX; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/neuroprotective-agent-5.html

Smiles

FCCO/N=C(CN1C=CN=C1)/C2=CC(OCO3)=C3C=C2

Molecular Formula

C14H14FN3O3

Molecular Weight

291.28

References & Citations

[1]Bian Z Y, et al. Design, Synthesis, and Biological Evaluation of Imidazolylacetophenone Oxime Derivatives as Novel Brain-Penetrant Agents for Alzheimer’s Disease Treatment[J]. European Journal of Medicinal Chemistry, 2024: 116794.