NSC15520

NSC15520 is a small molecular inhibitor of Replication Protein A (RPA) . NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1].

Product Specifications

CAS Number

[730960-98-2]

UNSPSC

12352211

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc15520.html

Purity

99.90

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

C[C@@]1(C(O)=O)CCC[C@]2(C)[C@]3([H])[C@]4(C(C(O)=O)[C@H]([C@@H](C3)C(C(C)C)=C4)C(O)=O)CC[C@@]12[H]

Molecular Formula

C24H34O6

Molecular Weight

418.52

References & Citations

[1]Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19 (8) :2589-95.