OP-5244
OP-5244 is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research[1].
Product Specifications
CAS Number
2381268-71-7
UNSPSC
12352005
Target
CD73
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/op-5244.html
Purity
99.07
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@@H]1CO[C@]([P](O)(O)=O)(COC)CO
Molecular Formula
C19H29ClN5O9P
Molecular Weight
537.89
References & Citations
[1]Du X, et, al. Orally Bioavailable Small Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression Through Blockade of Adenosine Production. J Med Chem. 2020 Aug 31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EK3591 Inquire
Rat 2',3'-cyclic-nucleotide 3'-phosphodiesterase ELISA Kit
Sign In for Pricing
View Details 
NBP2-76484-25ul 25 µL
Mouse Monoclonal Integrin beta 3/CD61 Antibody (CL7319)
Sign In for Pricing
View Details