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Cetirizine-d4 (dihydrochloride)

Cetirizine-d4 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

Product Specifications

UNSPSC

12352005

Target

Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C(N2CCN(C([2H])([2H])C([2H])([2H])OCC(O)=O)CC2)C3=CC=CC=C3)C=C1.Cl.Cl

Molecular Formula

C21H23D4Cl3N2O3

Molecular Weight

465.83

References & Citations

[1]Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6) : 1055•1080, 1993.|[2]Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29 (5) :480-5.|[3]Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34 (1) :103-9.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

H1 Receptor

Available Sizes

Curated Selection

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