LDN-192960 (hydrochloride)

LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].

Product Specifications

CAS Number

[2309172-48-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DYRK; Haspin Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldn-192960-hydrochloride.html

Purity

99.76

Solubility

DMSO : 7.14 mg/mL (ultrasonic)

Smiles

NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31.Cl.Cl

Molecular Formula

C18H22Cl2N2O2S

Molecular Weight

401.35

Precautions

H315, H319, H335

References & Citations

[1]Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20 (12) :3491-4.|[2]Gregory D Cuny, et al. Structure-activity Relationship Study of Acridine Analogs as Haspin and DYRK2 Kinase Inhibitors. Bioorg Med Chem Lett