Tonabersat
Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].
Product Specifications
CAS Number
[175013-84-0]
Product Name Alternative
SB-220453
UNSPSC
12352005
Hazard Statement
H315, H319, H400
Target
Gap Junction Protein
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tonabersat.html
Purity
99.68
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O
Molecular Formula
C20H19ClFNO4
Molecular Weight
391.82
Precautions
H315, H319, H400
References & Citations
[1]Silberstein SD, et al.
 Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine.
 Cephalalgia. 2009 Nov;29 Suppl 2:17-27.|[2]Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533 (7604) :493-8.|[3]Kim Y, et al. Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels. Neurotherapeutics. 2017 May 30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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