Tonabersat

Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].

Product Specifications

CAS Number

[175013-84-0]

Product Name Alternative

SB-220453

UNSPSC

12352005

Hazard Statement

H315, H319, H400

Target

Gap Junction Protein

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tonabersat.html

Purity

99.68

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O

Molecular Formula

C20H19ClFNO4

Molecular Weight

391.82

Precautions

H315, H319, H400

References & Citations

[1]Silberstein SD, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.|[2]Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533 (7604) :493-8.|[3]Kim Y, et al. Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels. Neurotherapeutics. 2017 May 30.