Aldosterone

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

Product Specifications

CAS Number

[52-39-1]

Product Name Alternative

E64d; E64c ethyl ester

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/aldosterone.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(CO)=O)CC[C@@]4([H])[C@]3([H])CCC1=CC(CC2)=O

Molecular Formula

C21H28O5

Molecular Weight

360.44

Precautions

H302, H312, H332

References & Citations

[1]Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71 (2) :218-223.|[2]Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.|[3]Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290 (2) :69-73.|[4]Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9 (10) :e111104.|[5]Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.