Fluazinam

Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[79622-59-6]

UNSPSC

12352005

Hazard Statement

H315, H318, H332, H361, H400, H410

Target

Apoptosis; Autophagy; Bcl-2 Family; Caspase; Fungal; JNK; p38 MAPK

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Fluazinam.html

Purity

99.36

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(C1=CN=C(NC2=C([N+]([O-])=O)C=C(C(F)(F)F)C(Cl)=C2[N+]([O-])=O)C(Cl)=C1)(F)F

Molecular Formula

C13H4Cl2F6N4O4

Molecular Weight

465.09

Precautions

H315, H318, H332, H361, H400, H410

References & Citations

[1]Hou YP, et al. Impact of fluazinam on morphological and physiological characteristics of Sclerotinia sclerotiorum. Pestic Biochem Physiol. 2019 Mar;155:81-89.|[2]Lee JE, et al. Fluazinam targets mitochondrial complex I to induce reactive oxygen species-dependent cytotoxicity in SH-SY5Y cells. Neurochem Int. 2012 Jun;60 (8) :773-81.|[3]Chen YL, et al. Activity of the dinitroaniline fungicide fluazinam against Bipolaris maydis. Pestic Biochem Physiol. 2018 Jun;148:8-15.|[4]Qu XP, et al. Effects of the dinitroaniline fungicide fluazinam on Fusarium fujikuroi and rice. Pestic Biochem Physiol. 2018 Nov;152:98-105.|[5]Wang XH, et al. Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere. 2018 Nov;210:633-644. |[6]Wu W, et al. Acute toxicity of fluazinam to aquatic organisms and its bioaccumulation in Brachydanio rerio. Environ Sci Pollut Res Int. 2020 Oct;27 (28) :35000-35007.|[7]Gomes DS, et al. Acute exposure to fungicide fluazinam induces cell death in the midgut, oxidative stress and alters behavior of the stingless bee Partamona helleri (Hymenoptera: Apidae) . Ecotoxicol Environ Saf. 2024 Sep 1;282:116677.