HA-1004
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models[1][2][3].
Product Specifications
CAS Number
91742-10-8
UNSPSC
12352005
Target
Calcium Channel; Cyclic GMP-AMP Synthase; ERK; PKA; Tyrosine Hydroxylase
Type
Reference compound
Related Pathways
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ha-1004.html
Purity
99.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC(N)=N)=O
Molecular Formula
C12H15N5O2S
Molecular Weight
293.34
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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