AZD7624

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

Product Specifications

CAS Number

[1095004-78-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/AZD7624.html

Purity

98.09

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2

Molecular Formula

C27H30FN5O3

Molecular Weight

491.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365 (3) :567-572.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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