Eriodictyol-7-O-glucoside

Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is an Nrf2 activator. Eriodictyol-7-O-glucoside exhibits significant scavenging effects on both hydroxyl radicals and superoxide anions, with IC50 values of 0.28 mM and 0.30 mM, respectively. Eriodictyol-7-O-glucoside increases the nuclear localization of Nrf2 and induces the expression of the Nrf2/ARE-dependent genes. Eriodictyol-7-O-glucoside provides protection against oxygen and glucose deprivation (OGD) -induced oxidative insult. Eriodictyol-7-O-glucoside demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia (MCAO) . Eriodictyol-7-O-glucoside can be used for the study of stroke[1][2][3].

Product Specifications

CAS Number

[38965-51-4]

Product Name Alternative

Eriodictyol 7-O-β-D-glucoside

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Keap1-Nrf2

Type

Natural Products

Related Pathways

NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eriodictyol-7-o-glucoside.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2O[C@H](C4=CC(O)=C(C=C4)O)C1

Molecular Formula

C21H22O11

Molecular Weight

450.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Hu Q, et al. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem Toxicol. 2012 Jun;50 (6) :1927-32. |[2]Jing X, et al. Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. Toxicol Appl Pharmacol. 2013 Dec 15;273 (3) :672-9. |[3]Yao H, et al. Antioxidative flavanone glycosides from the branches and leaves of Viscum coloratum. Chem Pharm Bull (Tokyo) . 2006 Jan;54 (1) :133-5.