KPLH1130
Product Specifications
UNSPSC Description
KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice[1].
Target Antigen
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kplh1130.html
Purity
99.86
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NNC(N2C3=CC=C(C)C=C3)=O)C(O)=C1
Molecular Weight
283.28
References & Citations
[1]Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128578/KPLH1130-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128578/KPLH1130-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
906669-07-6
Available Sizes
Curated Selection
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