Gly-Gly-Gly-PEG4-azide
Gly-Gly-Gly-PEG4-azide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Gly-Gly-Gly-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[3070260-22-6]
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gly-gly-gly-peg4-azide.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CN)NCC(NCC(NCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O
Molecular Formula
C16H31N7O7
Molecular Weight
433.46
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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