Vitamin K4

Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma[1][2].

Product Specifications

CAS Number

[573-20-6]

Product Name Alternative

Acetomenaphthone

UNSPSC

12352005

Hazard Statement

H318

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Vitamin_K4.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(OC(C)=O)=C2C=CC=CC2=C1OC(C)=O

Molecular Formula

C15H14O4

Molecular Weight

258.27

Precautions

H318

References & Citations

[1]Jiang Y, et al. Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway. Pharmazie. 2013 Jun;68 (6) :442-8.|[2]Di W, et al. Vitamin K4 inhibits the proliferation and induces apoptosis of U2OS osteosarcoma cells via mitochondrial dysfunction. Mol Med Rep. 2017 Jan;15 (1) :277-284.