What is the catalog number for C75?

The catalog number for C75 is HY-12364.

What sizes are available for C75?

C75 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does C75 come in?

C75 is available in 6 different pack sizes.

C75 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures C75?

C75 is manufactured by QuantiMol.

What is the estimated delivery time for C75?

Estimated delivery time for C75 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for C75?

The safety data sheet for C75 is available here: http://file.medchemexpress.com/batch_PDF/HY-12364/C75-SDS-MedChemExpress.pdf.

C75

C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].

Product Specifications

CAS Number

218137-86-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/C75.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(C(C1=C)C(CCCCCCCC)OC1=O)O

Molecular Formula

C14H22O4

Molecular Weight

254.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.|[2]Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+) -C75 is a strong anorectic drug; (-) -C75 has antitumor activity. Chirality. 2013 May;25 (5) :281-7.|[3]Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100 (10) :5628-33.|[4]Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99 (14) :9498-502.|[5] Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105 (3) :550-560.