LY2812223
LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively) [1].
Product Specifications
CAS Number
1311385-20-2
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly2812223.html
Purity
98.0
Solubility
DMSO : 28.75 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
[H][C@]1(C(O)=O)[C@]([C@]1([H])[C@](N)(C(O)=O)C2)([H])[C@@H]2SC3=NN=CN3
Molecular Formula
C10H12N4O4S
Molecular Weight
284.29
References & Citations
[1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4- (Thiotriazolyl) -substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R) -2-Amino-4- (1H-1,2,4-triazol-3-ylsulfanyl) bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58 (18) :7526-48.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3
Available Sizes
Frequently Asked Questions
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