LY2812223

LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively) [1].

Product Specifications

CAS Number

[1311385-20-2]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly2812223.html

Purity

98.0

Solubility

DMSO : 28.75 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

[H][C@]1(C(O)=O)[C@]([C@]1([H])[C@](N)(C(O)=O)C2)([H])[C@@H]2SC3=NN=CN3

Molecular Formula

C10H12N4O4S

Molecular Weight

284.29

References & Citations

[1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4- (Thiotriazolyl) -substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R) -2-Amino-4- (1H-1,2,4-triazol-3-ylsulfanyl) bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58 (18) :7526-48.