P-gp inhibitor 21
P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity[1].
Product Specifications
UNSPSC
12352209
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-21.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCCCCCCCCCC(N[C@H]1C(C)C)=O)N[C@H](COC1=O)CC2=CC=CC=C2
Molecular Formula
C27H42N2O4
Molecular Weight
458.63
References & Citations
[1]Yang GZ, et al., Design and Synthesis of Cyclolipopeptide Mimics of Dysoxylactam A and Evaluation of the Reversing Potencies against P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem. 2024 Mar 28;67 (6) :4560-4582.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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