2,3-Diaminophenazine

2,3-Diaminophenazine (2,3-Phenazinediamine) is an orally active amino derivative of phenazine. 2,3-Diaminophenazine can intercalate into DNA. 2,3-Diaminophenazine triggers photochemical reactions. 2,3-Diaminophenazine inhibits vascular hypertrophy and tissue AGE deposition in diabetic rats. 2,3-Diaminophenazine can be used for luminescence and diabetes research[1][2][3][4].

Product Specifications

CAS Number

[655-86-7]

Product Name Alternative

2,3-Phenazinediamine; NNC39-0028

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

DNA Alkylator/Crosslinker; Fluorescent Dye

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-3-diaminophenazine.html

Purity

99.84

Solubility

DMSO : 5.83 mg/mL (ultrasonic)

Smiles

NC1=CC2=NC3=CC=CC=C3N=C2C=C1N

Molecular Formula

C12H10N4

Molecular Weight

210.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Xiaoyue He, et al. Selective self-assembly of 2,3-diaminophenazine molecules on MoSe 2 mirror twin boundaries. Nat Commun. 2019 Jun 28;10 (1) :2847.|[2]Feng Zhang, et al. An enzymatic ratiometric fluorescence assay for 6-mercaptopurine by using MoS 2 quantum dots. Mikrochim Acta. 2018 Nov 10;185 (12) :540.|[3]Fu PK, et al. Photoinduced DNA cleavage and cellular damage in human dermal fibroblasts by 2,3-diaminophenazine. Photochem Photobiol. 2005 Jan-Feb;81 (1) :89-95.|[4]Soulis T, et al. A novel inhibitor of advanced glycation end-product formation inhibits mesenteric vascular hypertrophy in experimental diabetes. Diabetologia. 1999 Apr;42 (4) :472-9.