Ebselen
Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM) [3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].
Product Specifications
CAS Number
[60940-34-3]
Product Name Alternative
SPI-1005; PZ-51; CCG-39161
UNSPSC
12352005
Hazard Statement
H301+H331, H373, H410
Target
Calcium Channel; HIV; Phosphatase; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ebselen.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3
Molecular Formula
C13H9NOSe
Molecular Weight
274.18
Precautions
H301+H331, H373, H410
References & Citations
Pro
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1
Available Sizes
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