Raxatrigine (hydrochloride)

Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

Product Specifications

CAS Number

[934240-31-0]

Product Name Alternative

Vixotrigine (hydrochloride) ; GSK-1014802 (hydrochloride) ; CNV1014802 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CNV1014802-hydrochloride.html

Purity

99.10

Solubility

DMSO : ≥ 31 mg/mL|H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N[C@@H](C2=CC=C(OCC3=CC=CC=C3F)C=C2)CC1)N.[H]Cl

Molecular Formula

C18H20ClFN2O2

Molecular Weight

350.82

Precautions

H302, H315, H319, H335

References & Citations

[1]Large CH, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia. J Pharmacol Exp Ther. 2011 Jul;338 (1) :100-13.