2-Deoxy-2-fluoro-L-fucose

2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1].

Product Specifications

CAS Number

[70763-62-1]

Product Name Alternative

Adonitol-5-13C; Adonite-5-13C,Adonitol-3-13C; Adonite-3-13C

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Glycosyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-deoxy-2-fluoro-l-fucose.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C[C@@H](F)[C@@H]([C@@H]([C@H](C)O)O)O

Molecular Formula

C6H11FO4

Molecular Weight

166.15

Precautions

H302, H312, H332

References & Citations

[1]Herrera H, et al. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019;20 (10) :2528. Published 2019 May 23.