CW-069
CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC50 of 75 μM.
Product Specifications
CAS Number
[1594094-64-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CW-069.html
Purity
99.37
Solubility
DMSO : ≥ 52 mg/mL
Smiles
O=C(NC1=CC=C(I)C=C1C(O)=O)[C@@H](NCC2=CC=CC=C2)CC3=CC=CC=C3
Molecular Formula
C23H21IN2O3
Molecular Weight
500.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Watts CA, et al. Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes. Chem Biol. 2013 Nov 21;20 (11) :1399-410.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-14
Available Sizes
Curated Selection
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