Biotinylated Cynomolgus Cadherin-17 / CDH17 Protein, His,Avitag™ (MALS verified)

Biotinylated Cynomolgus Cadherin-17 Protein, His,Avitag (CA7-C82E8) is expressed from human 293 cells (HEK293). It contains AA Lys 30 - Thr 792 (Accession # A0A2K5X8I8-1).

Product Specifications

Background

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 88.3 kDa. The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Lys 30 - Thr 792

Host

HEK 293

Target

Cadherin-17

Conjugation

Biotin-labeled

Tag

C-10×His & C-Avi

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Biotinylated Cynomolgus Cadherin-17 Protein, His,Avitag (Cat. No. CA7-C82E8) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-CDH17 Antibody with a linear range of 2-31 ng/mL (QC tested).