CCK-B Receptor Antagonist 2

CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM[1].

Product Specifications

CAS Number

[155412-88-7]

UNSPSC

12352005

Target

Cholecystokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cck-b-receptor-antagonist-2.html

Concentration

10mM

Purity

98.84

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=C(N[C@H]1C(N(CC(C(C)(C)C)=O)C2=CC=CC=C2C(C3=NC=CC=C3)=N1)=O)NC4=CC=CC(N)=C4

Molecular Formula

C27H28N6O3

Molecular Weight

484.55

References & Citations

[1]Semple G, et al. (3R) -N- (1- (tert-butylcarbonylmethyl) -2,3-dihydro-2-oxo-5- (2-pyridyl) -1H-1,4-benzodiazepin-3-yl) -N'- (3- (methylamino) phenyl) urea (YF476) : a potent and orally active gastrin/CCK-B antagonist.J Med Chem. 1997 Jan 31;40 (3) :331-41.