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A2AAR antagonist 2

3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research[1].

Product Specifications

UNSPSC

12352005

Target

Adenosine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/a2aar-antagonist-2.html

Concentration

10mM

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC(C=CO2)=C2C=C1)C3=CC=CC(OC)=C3

Molecular Formula

C18H14O3

Molecular Weight

278.30

References & Citations

[1]Zhang RJ, et al. Exploring the Immunomodulatory Properties of Red Onion (Allium cepa L.) Skin: Isolation, Structural Elucidation, and Bioactivity Study of Novel Onion Chalcones Targeting the A2A Adenosine Receptor. J Agric Food Chem. 2023 Nov 6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Adenosine A2A receptor (A2AR)

Available Sizes

Frequently Asked Questions

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