AdipoR agonist 1

AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK) . AdipoR agonist 1 is utilized in preventive doping research[1].

Product Specifications

CAS Number

[949745-75-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adiponectin Receptor; AMPK; PGC-1α; PPAR; Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/adipor-agonist-1.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

O=C(NCCC(N1CCN(CC2=CC=C(OC)C=C2)CC1)=O)C3=CC=C(C(C)(C)C)C=C3

Molecular Formula

C26H35N3O3

Molecular Weight

437.57

Precautions

H315, H319, H335

References & Citations

[1]Dib J, et al., Identification and characterization of in vitro and in vivo generated metabolites of the adiponectin receptor agonists AdipoRon and 112254. J Pharm Biomed Anal. 2016 Jun 5;125:68-76.