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XQ2B

XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1) -induced antiviral immune responses and enhances HSV-1 infection[1].

Product Specifications

CAS Number

[2104728-28-9]

UNSPSC

12352209

Target

Autophagy; Cyclic GMP-AMP Synthase

Type

Peptides

Related Pathways

Autophagy; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/xq2b.html

Purity

99.45

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H]1N(C([C@@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@@H](N3)CCCNC(N)=N)=O)=O)=O)CCC1)=O)=O)=O)N[C@@H](C(N[C@@H](C)C(N[C@]([C@H](O)C)([H])C3=O)=O)=O)CC4=CC=CC=C4

Molecular Formula

C59H92N16O11

Molecular Weight

1201.46

References & Citations

[1]Wang X, et al. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nat Commun. 2023 Oct 2;14 (1) :6132.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P5997/XQ2B-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P5997/XQ2B-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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