FR901464

FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

Product Specifications

CAS Number

[146478-72-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H351

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fr901464.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H](O1)/C=C/C(C)=C/C[C@H](O[C@@H]2C)[C@H](C[C@H]2NC(/C=C\[C@H](C)OC(C)=O)=O)C)[C@@]3(C[C@]1(O)C)CO3

Molecular Formula

C27H41NO8

Molecular Weight

507.62

Precautions

H315, H319, H351

References & Citations

[1]H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo) . 1996 Dec;49 (12) :1204-11.|[2]Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79 (12) :5697-709.