Thalidomide-5-PEG4-NH2 (hydrochloride)

Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2743434-24-2]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-peg4-nh2-hydrochloride.html

Purity

95.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCCOCCOCCOCCOC1=CC(C(N2C(C3=O)CCC(N3)=O)=O)=C(C=C1)C2=O.Cl

Molecular Formula

C21H28ClN3O8

Molecular Weight

485.92

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-994.