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TRV056

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R) . TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1].

Product Specifications

CAS Number

812644-79-4

UNSPSC

12352209

Target

Angiotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trv056.html

Purity

99.91

Solubility

H2O : 1.96 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)=O)CC(C=C3)=CC=C3O)=O)=O)CC4=CN=CN4

Molecular Formula

C52H74N14O13

Molecular Weight

1103.23

References & Citations

[1]Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176 (3) :468-478.e11.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

AT1 Receptor

Available Sizes

Frequently Asked Questions

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