ATR-IN-4
ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13) [1].
Product Specifications
CAS Number
[2574545-45-0]
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-4.html
Concentration
10mM
Purity
98.35
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN1C(C2=CC(N3[C@@H](COCC3)C)=NN4C2=CN=C4C5=NNC=C5)=CC=N1
Molecular Formula
C18H20N8O
Molecular Weight
364.40
References & Citations
[1]Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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