Buntanetap (L-Tartrate)

Buntanetap L-Tartrate (Phenserine L-Tartrate) is a selective AChE inhibitor (IC50 = 22.2 nM) . Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT) . Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease[1][2][3][4].

Product Specifications

CAS Number

[865795-23-9]

Product Name Alternative

(+) -Phenserine (L-Tartrate) ; ANVS401 (L-Tartrate)

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/buntanetap-l-tartrate.html

Purity

98.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1[C@@](N(C)CC2)([H])[C@@]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3.OC([C@H](O)[C@@H](O)C(O)=O)=O

Molecular Formula

C24H29N3O8

Molecular Weight

487.50

References & Citations

[1]Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. J Prev Alzheimers Dis. 2023;10 (1) :25-33. |[2]Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13 (12) :2109.|[3]Brossi A , Pei XF Greig NH (1996) Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties. Australian Journal of Chemistry 49, 171-181.|[4]Fang, C., et al., (2023) . Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients. The journal of prevention of Alzheimer's disease, 10 (1), 25–33.