Human PTK7 / CCK4 Protein, Fc Tag (MALS verified)
Human PTK7, Fc Tag (PT7-H5253) is expressed from human 293 cells (HEK293) . It contains AA Ala 31 - Thr 704 (Accession # Q13308-1) .
Product Specifications
Background
PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 101.1 kDa. The protein migrates as 125-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q13308-1
Expression Region
Ala 31 - Thr 704
Host
HEK293
Target
PTK7
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Immobilized Human PTK7, Fc Tag (Cat. No. PT7-H5253) at 1 μg/mL (100 μL/well) can bind Cofetuzumab Pelidotin with a linear range of 0.06-8 ng/mL (QC tested).
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
101.1 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/PT7-H5253.pdf
Species
Human
Curated Selection
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